Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers

Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers

Abstract Background Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target module (TM) which is characterized by a small-size and short half-life. T...

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Bibliographic Details
Main Authors: Liliana R. Loureiro, Anja Feldmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Domokos Máthé, Nikolett Hegedüs, Krisztián Szigeti, Paula A. Videira, Michael Bachmann, Claudia Arndt
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Immunotherapy
UniCAR T-cells
IgG4-based TM
Sialyl-Tn (STn)
Online Access:http://link.springer.com/article/10.1186/s13046-020-01572-4

Internet

http://link.springer.com/article/10.1186/s13046-020-01572-4

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