Membrane binding, internalization, and sorting of alpha-synuclein in the cell

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

Abstract Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions. While the function of aSyn is thought to be related to vesicle binding and trafficking, the precise molecular mechanism...

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Bibliographic Details
Main Authors: Caterina Masaracchia, Marilena Hnida, Ellen Gerhardt, Tomás Lopes da Fonseca, Anna Villar-Pique, Tiago Branco, Markus A. Stahlberg, Camin Dean, Claudio O. Fernández, Ira Milosevic, Tiago F. Outeiro
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Acta Neuropathologica Communications
Subjects:
Alpha-synuclein
Parkinson’s disease
Uptake
Spreading
Rab proteins
Online Access:http://link.springer.com/article/10.1186/s40478-018-0578-1

Internet

http://link.springer.com/article/10.1186/s40478-018-0578-1

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