A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation.

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation.

The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL). Although both molecules are active for human TLR4, they demonstrate a potency preference for mouse TLR4 based on data from transfe...

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Bibliographic Details
Main Authors: Jason D Marshall, Darren S Heeke, Eileen Rao, Sean K Maynard, David Hornigold, Christopher McCrae, Neil Fraser, Andrey Tovchigrechko, Li Yu, Nicola Williams, Sarah King, Martin E Cooper, Adeline M Hajjar, Jennifer C Woo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5063506?pdf=render

Internet

http://europepmc.org/articles/PMC5063506?pdf=render

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