Identification and characterization of the direct interaction between methotrexate (MTX) and high-mobility group box 1 (HMGB1) protein.

Identification and characterization of the direct interaction between methotrexate (MTX) and high-mobility group box 1 (HMGB1) protein.

BACKGROUND: Methotrexate (MTX) is an agent used in chemotherapy of tumors and autoimmune disease including rheumatoid arthritis (RA). In addition, MTX has some anti-inflammatory activity. Although dihydrofolate reductase (DHFR) is a well-known target for the anti-tumor effect of MTX, the mode of act...

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Bibliographic Details
Main Authors: Yuki Kuroiwa, Yoichi Takakusagi, Tomoe Kusayanagi, Kouji Kuramochi, Takahiko Imai, Tomoko Hirayama, Ichiaki Ito, Michiteru Yoshida, Kengo Sakaguchi, Fumio Sugawara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3643934?pdf=render

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http://europepmc.org/articles/PMC3643934?pdf=render

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