Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

Pharmacological interventions targeting mitochondria present several barriers for a complete efficacy. Therefore, a new mitochondriotropic antioxidant (AntiOxBEN3) based on the dietary antioxidant gallic acid was developed. AntiOxBEN3 accumulated several thousand-fold inside isolated rat liver mitoc...

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Bibliographic Details
Main Authors: José Teixeira, Catarina Oliveira, Fernando Cagide, Ricardo Amorim, Jorge Garrido, Fernanda Borges, Paulo J. Oliveira
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Gallic acid
mitochondriotropic antioxidant
oxidative stress
mitochondrial dysfunction
mitochondrial permeability transition pore
Online Access:http://dx.doi.org/10.1080/14756366.2018.1442831

Internet

http://dx.doi.org/10.1080/14756366.2018.1442831

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