Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.

BACKGROUND:The long term and complex nature of Chagas disease in humans has restricted studies on vaccine feasibility. Animal models also have limitations due to technical difficulties in monitoring the extremely low parasite burden that is characteristic of chronic stage infections. Advances in ima...

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Main Authors: Gurdip Singh Mann, Amanda F Francisco, Shiromani Jayawardhana, Martin C Taylor, Michael D Lewis, Francisco Olmo, Elisangela Oliveira de Freitas, Fabiana M S Leoratti, Cesar López-Camacho, Arturo Reyes-Sandoval, John M Kelly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007717