Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used...

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Main Authors:	Alice E. Law, Rebecca K. Shears, Andrea A. Lopez Rodas, Richard K. Grencis, Philip J. Cooper, Daniel R. Neill, Aras Kadioglu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-86508-4

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spelling	doaj-a8bb4f2f12d842e99dc75046011d68e12021-03-28T11:29:54ZengNature Publishing GroupScientific Reports2045-23222021-03-011111610.1038/s41598-021-86508-4Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive diseaseAlice E. Law0Rebecca K. Shears1Andrea A. Lopez Rodas2Richard K. Grencis3Philip J. Cooper4Daniel R. Neill5Aras Kadioglu6Department of Clinical Immunology, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolDepartment of Clinical Immunology, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolSchool of Medicine, Universidad Internacional del EcuadorSchool of Biological Sciences, Lydia Becker Institute of Immunology and Inflammation, Wellcome Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of ManchesterSchool of Medicine, Universidad Internacional del EcuadorDepartment of Clinical Immunology, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolDepartment of Clinical Immunology, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolAbstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.https://doi.org/10.1038/s41598-021-86508-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alice E. Law Rebecca K. Shears Andrea A. Lopez Rodas Richard K. Grencis Philip J. Cooper Daniel R. Neill Aras Kadioglu
spellingShingle	Alice E. Law Rebecca K. Shears Andrea A. Lopez Rodas Richard K. Grencis Philip J. Cooper Daniel R. Neill Aras Kadioglu Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease Scientific Reports
author_facet	Alice E. Law Rebecca K. Shears Andrea A. Lopez Rodas Richard K. Grencis Philip J. Cooper Daniel R. Neill Aras Kadioglu
author_sort	Alice E. Law
title	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_short	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_full	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_fullStr	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_full_unstemmed	Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
title_sort	intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
publisher	Nature Publishing Group
series	Scientific Reports
issn	2045-2322
publishDate	2021-03-01
description	Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.
url	https://doi.org/10.1038/s41598-021-86508-4
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Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

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