Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells

Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells

Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent and invisible to clearance by the immune system. To demonstrate that the latency reversing agent vorinostat (VOR) induces a window of vulnerability in the latent HIV reservoir, defined as the triggering of vir...

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Bibliographic Details
Main Authors: Julia A. Sung, Katherine Sholtis, Jennifer Kirchherr, Joann D. Kuruc, Cynthia L. Gay, Jeffrey L. Nordstrom, Catherine M. Bollard, Nancie M. Archin, David M. Margolis
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:EBioMedicine
Subjects:
HIV
Latency
Eradication
Vorinostat
Immune effector
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641730292X

Internet

http://www.sciencedirect.com/science/article/pii/S235239641730292X

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