Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models

Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models

Correlative studies of clinical studies for hematological malignancies have implicated that less differentiated, CD8+-dominant CAR T cell products have greater antitumor activity. Here, we have investigated whether the differentiation status of CAR T cell products affects their antitumor activity in...

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Bibliographic Details
Main Authors: Marianna Csaplár, János Szöllősi, Stephen Gottschalk, György Vereb, Árpád Szöőr
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
solid tumor
chimeric antigen receptor (CAR)
immunotherapy
cell therapy
T cell expansion
T cell persistence
Online Access:https://www.mdpi.com/2072-6694/13/17/4301

Internet

https://www.mdpi.com/2072-6694/13/17/4301

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