Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies

Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies

Abstract RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain unclear. In an unbiased screen in Drosophila for RBPs that genetically interact with TDP-43, we found that downregulation of th...

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Bibliographic Details
Main Authors: Amit Berson, Lindsey D. Goodman, Ashley N. Sartoris, Charlton G. Otte, James A. Aykit, Virginia M.-Y. Lee, John Q. Trojanowski, Nancy M. Bonini
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Acta Neuropathologica Communications
Subjects:
ALYREF
Ref1
Drosophila
Amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease)
Ataxin-2
C9orf72
Online Access:http://link.springer.com/article/10.1186/s40478-019-0710-x

Internet

http://link.springer.com/article/10.1186/s40478-019-0710-x

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