Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis

Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis

Abstract Background The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and therefore cytoskeleton-associated proteins are interesting targets for...

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Bibliographic Details
Main Authors: Julia Arnold, Juliana Schattschneider, Christine Blechner, Christoph Krisp, Hartmut Schlüter, Michaela Schweizer, Marcus Nalaskowski, Leticia Oliveira-Ferrer, Sabine Windhorst
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
Metastasis
Exosome
Microtubule
Polyglutamylation
Online Access:http://link.springer.com/article/10.1186/s13046-020-01712-w

Internet

http://link.springer.com/article/10.1186/s13046-020-01712-w

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