Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis

Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis

In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lactate, the end-product of glycolysis, accumulates in...

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Bibliographic Details
Main Authors: Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
lactate
human
macrophage
glycolysis
metabolism
tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.663695/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.663695/full

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