Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions

Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions

Vanishing white matter (VWM) is a leukodystrophy with predominantly early-childhood onset. Affected children display various neurological signs, including ataxia and spasticity, and die early. VWM patients have bi-allelic mutations in any of the five genes encoding the subunits of the eukaryotic tra...

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Bibliographic Details
Main Authors: Lisanne E. Wisse, Renske Penning, Esther A. Zaal, Carola G. M. van Berkel, Timo J. ter Braak, Emiel Polder, Justin W. Kenney, Christopher G. Proud, Celia R. Berkers, Maarten A. F. Altelaar, Dave Speijer, Marjo S. van der Knaap, Truus E. M. Abbink
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
vanishing white matter
eIF2B
AHA
SILAC
astrocytes
metabolomics
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00411/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00411/full

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