Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record

Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record

Abstract Background The growth of DNA biobanks linked to data from electronic health records (EHRs) has enabled the discovery of numerous associations between genomic variants and clinical phenotypes. Nonetheless, although clinical data are generally longitudinal, standard approaches for detecting g...

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Bibliographic Details
Main Authors: Jacob J. Hughey, Seth D. Rhoades, Darwin Y. Fu, Lisa Bastarache, Joshua C. Denny, Qingxia Chen
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Genomics
Subjects:
GWAS
Electronic health record
Time-to-event modeling
Cox regression
Online Access:http://link.springer.com/article/10.1186/s12864-019-6192-1

Internet

http://link.springer.com/article/10.1186/s12864-019-6192-1

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