Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. p53 activates NGFR transcription, whereas NGFR inactivates p53 by promoting its MDM2-mediated ubiquitin-dependent proteolysis and by directly bin...

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Bibliographic Details
Main Authors: Xiang Zhou, Qian Hao, Peng Liao, Shiwen Luo, Minhong Zhang, Guohui Hu, Hongbing Liu, Yiwei Zhang, Bo Cao, Melody Baddoo, Erik K Flemington, Shelya X Zeng, Hua Lu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
NGFR
p53
MDM2
protein stability
transcriptional regulation
cell viability
Online Access:https://elifesciences.org/articles/15099

Internet

https://elifesciences.org/articles/15099

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