Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Abstract Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis. CD300f −/− mice were protected from death after ce...

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Bibliographic Details
Main Authors: Kumi Izawa, Akie Maehara, Masamichi Isobe, Yuka Yasuda, Makoto Urai, Yasutaka Hoshino, Keigo Ueno, Toshihiro Matsukawa, Mariko Takahashi, Ayako Kaitani, Emiko Shiba, Ayako Takamori, Shino Uchida, Koichiro Uchida, Keiko Maeda, Nobuhiro Nakano, Yoshinori Yamanishi, Toshihiko Oki, David Voehringer, Axel Roers, Susumu Nakae, Junko Ishikawa, Yuki Kinjo, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Toshio Kitamura, Jiro Kitaura
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04647-z

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https://doi.org/10.1038/s41598-017-04647-z

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