Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

Massive neuronal loss is a key pathological hallmark of Alzheimer's disease (AD). However, the mechanisms are still unclear. Here we demonstrate that neuroinflammation, cell autonomous to microglia, is capable of inducing neuronal cell cycle events (CCEs), which are toxic for terminally differe...

Full description

Bibliographic Details
Main Authors: Kiran Bhaskar, Nicole Maphis, Guixiang Xu, Nicholas H. Varvel, Olga N. Kokiko-Cochran, Jason P. Weick, Susan M. Staugaitis, Astrid Cardona, Richard M. Ransohoff, Karl Herrup, Bruce T. Lamb
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Microglia
Neuronal cell cycle
Tumor necrosis factor-α (TNFα)
Neuroinflammation
Adoptive transfer
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002829

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113002829

Similar Items