Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

Cell wall biosynthesis inhibitors have proven highly effective for treating tuberculosis (TB). We discovered and validated members of the indazole sulfonamide class of small molecules as inhibitors of Mycobacterium tuberculosis KasA—a key component for biosynthesis of the mycolic acid layer of the b...

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Bibliographic Details
Main Authors: Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mBio
Subjects:
antitubercular
DG167
KasA
Mycobacterium tuberculosis
mycolic acid biosynthesis
drug development
isoniazid
synergistic lethality
Online Access:https://doi.org/10.1128/mBio.02101-17

Internet

https://doi.org/10.1128/mBio.02101-17

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