D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, anoikis, and differentiation block of hematopoietic...

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Bibliographic Details
Main Authors: Martin Böttcher, Kathrin Renner, Raffaela Berger, Kristin Mentz, Simone Thomas, Zugey Elizabeth Cardenas-Conejo, Katja Dettmer, Peter J. Oefner, Andreas Mackensen, Marina Kreutz, Dimitrios Mougiakakos
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:OncoImmunology
Subjects:
immunometabolism
oncometabolite
acute myeloid leukemia
idh mutation
th17
tregs
2hg
immunosurveillance
inflammation and cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1445454

Internet

http://dx.doi.org/10.1080/2162402X.2018.1445454

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