Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D<sub>2</sub> 3,4-dihydroquinolin-2(1<i>H</i>)-one Derivatives Related to Aripiprazole

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D<sub>2</sub> 3,4-dihydroquinolin-2(1<i>H</i>)-one Derivatives Related to Aripiprazole

In this pilot study, a series of new 3,4-dihydroquinolin-2(1<i>H</i>)-one derivatives as potential dopamine receptor D<sub>2</sub> (D<sub>2</sub>R) modulators were synthesized and evaluated in vitro. The preliminary structure–activity relationship disclosed that c...

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Bibliographic Details
Main Authors: Radomir Juza, Kristyna Stefkova, Wim Dehaen, Alena Randakova, Tomas Petrasek, Iveta Vojtechova, Tereza Kobrlova, Lenka Pulkrabkova, Lubica Muckova, Marko Mecava, Lukas Prchal, Eva Mezeiova, Kamil Musilek, Ondrej Soukup, Jan Korabecny
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
aripiprazole
dopamine receptor
blood–brain barrier
molecular modeling studies
schizophrenia
Online Access:https://www.mdpi.com/2218-273X/11/9/1262

Internet

https://www.mdpi.com/2218-273X/11/9/1262

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