Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer’s Disease Mutations

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer’s Disease Mutations

We investigated early phenotypes caused by familial Alzheimer’s disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci revealed that fAD mutant neurons had previously unre...

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Bibliographic Details
Main Authors: Grace Woodruff, Sol M. Reyna, Mariah Dunlap, Rik Van Der Kant, Julia A. Callender, Jessica E. Young, Elizabeth A. Roberts, Lawrence S.B. Goldstein
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
iPSC
FAD
APP
PS1
transcytosis
endocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312566

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http://www.sciencedirect.com/science/article/pii/S2211124716312566

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