Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of convertase bound FP. A structural core formed...

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Bibliographic Details
Main Authors: Dennis V. Pedersen, Trine A. F. Gadeberg, Caroline Thomas, Yong Wang, Nicolas Joram, Rasmus K. Jensen, Sofia M. M. Mazarakis, Margot Revel, Carine El Sissy, Steen V. Petersen, Kresten Lindorff-Larsen, Steffen Thiel, Nick S. Laursen, Véronique Fremeaux-Bacchi, Gregers R. Andersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
complement
convertase
properdin
complement component C3
crystal structure
regulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02007/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02007/full

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