The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metapha...

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Bibliographic Details
Main Authors: Sang-Min Jang, Jenny F. Nathans, Haiqing Fu, Christophe E. Redon, Lisa M. Jenkins, Bhushan L. Thakur, Lőrinc S. Pongor, Adrian M. Baris, Jacob M. Gross, Maura J. OʹNeill, Fred E. Indig, Steven D. Cappell, Mirit I. Aladjem
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13808-9

Internet

https://doi.org/10.1038/s41467-019-13808-9

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