Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer's Disease Treatment

Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer's Disease Treatment

A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was deter...

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Bibliographic Details
Main Authors: Jiri Patocka, Jan Korabecny, Kamil Kuca, Zdenek Fisar, Jana Hroudova, Florian Nachon, Vlastimil Dohnal, Filip Zemek, Veronika Opletalova, Daniel Jun, Eugenie Nepovimova, Ondrej Holas, Kamil Musilek
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
tacrine
acetylcholinesterase
butyrylcholinesterase
7-MEOTA
inhibition
Alzheimer disease
Online Access:http://www.mdpi.com/1420-3049/15/12/8804/

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http://www.mdpi.com/1420-3049/15/12/8804/

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