5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia

5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia

Abstract Thrombocytopenia 2 (THC2) is an inherited disorder caused by monoallelic single nucleotide substitutions in the 5’UTR of the ANKRD26 gene. Patients have thrombocytopenia and increased risk of myeloid malignancies, in particular, acute myeloid leukemia (AML). Given the association of variant...

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Bibliographic Details
Main Authors: Caterina Marconi, Ilaria Canobbio, Valeria Bozzi, Tommaso Pippucci, Giorgia Simonetti, Federica Melazzini, Silvia Angori, Giovanni Martinelli, Giuseppe Saglio, Mauro Torti, Ira Pastan, Marco Seri, Alessandro Pecci
Format: Article
Language:English
Published: BMC 2017-01-01
Series:Journal of Hematology & Oncology
Subjects:
ANKRD26 gene
Acute myeloid leukemia
Inherited predisposition to leukemia
Inherited thrombocytopenia
Online Access:http://link.springer.com/article/10.1186/s13045-016-0382-y

Internet

http://link.springer.com/article/10.1186/s13045-016-0382-y

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