Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

Background: Human tuberculosis (TB) is caused by a plethora of Mycobacterium tuberculosis complex (MTBC) strains belonging to seven phylogenetic branches. Lineages 2, 3 and 4 are considered “modern” branches of the MTBC responsible for the majority of worldwide TB. Since the current BCG vaccine conf...

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Bibliographic Details
Main Authors: Irene Pérez, Santiago Uranga, Fadel Sayes, Wafa Frigui, Sofía Samper, Ainhoa Arbués, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301365