Development of a fully automated chemiluminescence immunoassay for urine monomeric laminin-γ2 as a promising diagnostic tool of non-muscle invasive bladder cancer

Development of a fully automated chemiluminescence immunoassay for urine monomeric laminin-γ2 as a promising diagnostic tool of non-muscle invasive bladder cancer

Abstract Background Monomeric laminin-γ2 in urine is a potential biomarker for bladder cancer. However, the current detection system uses an antibody that cannot discriminate between monomeric laminin-γ2 and the heterotrimeric γ2 chain of laminin-332, which may cause false-positive reactions. The pr...

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Bibliographic Details
Main Authors: Masatoshi Nakagawa, Takashi Karashima, Masayuki Kamada, Eisaku Yoshida, Toru Yoshimura, Masanori Nojima, Keiji Inoue, Taro Shuin, Motoharu Seiki, Naohiko Koshikawa
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Biomarker Research
Subjects:
Urine biomarker
Chemiluminescence immunoassay (CLIA)
Monomeric laminin-γ2
Non-muscle invasive bladder cancer (NMIBC)
Online Access:http://link.springer.com/article/10.1186/s40364-017-0109-4

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http://link.springer.com/article/10.1186/s40364-017-0109-4

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