Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies

Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies

Human African Trypanosomiasis (HAT), a disease that provokes 2184 new cases a year in Sub-Saharan Africa, is caused by Trypanosoma brucei. Current treatments are limited, highly toxic, and parasite strains resistant to them are emerging. Therefore, there is an urgency to find new drugs against HAT....

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Bibliographic Details
Main Authors: Alejandra Vázquez-Raygoza, Lucia Cano-González, Israel Velázquez-Martínez, Pedro Josué Trejo-Soto, Rafael Castillo, Alicia Hernández-Campos, Francisco Hernández-Luis, Jesús Oria-Hernández, Adriana Castillo-Villanueva, Claudia Avitia-Domínguez, Erick Sierra-Campos, Mónica Valdez-Solana, Alfredo Téllez-Valencia
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
human African trypanosomiasis
triosephosphate isomerase
enzymatic kinetics
molecular dynamics simulation
Online Access:https://www.mdpi.com/1420-3049/22/12/2055

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https://www.mdpi.com/1420-3049/22/12/2055

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