LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Constitutive activation of the Hedgehog (Hh) signaling pathway has been implicated in the development of many human malignancies. Hh targets, such as Patched (PTCH), smoothened (SMO), Sonic hedgehog (SHH) and glioma-associated oncogene homologue 1 (GLI1), are markers of Hh signaling activation and e...

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Bibliographic Details
Main Authors: Zhigang Zhuang, Kai Wang, Xiaolin Cheng, Xueying Qu, Beiqi Jiang, Zhengdong Li, Jianming Luo, Zhiming Shao, Tao Duan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3701543?pdf=render

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http://europepmc.org/articles/PMC3701543?pdf=render

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