Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids

Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids

Radiation-induced normal tissue toxicity often limits the curative treatment of cancer. Moreover, normal tissue relative biological effectiveness data for high-linear energy transfer particles are urgently needed. We propose a strategy based on transcriptome analysis of patient-derived human intesti...

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Bibliographic Details
Main Authors: Ali Nowrouzi, Mathieu G. Sertorio, Mahdi Akbarpour, Maximillian Knoll, Damir Krunic, Matthew Kuhar, Christian Schwager, Stephan Brons, Jürgen Debus, Susanne I. Wells, James M. Wells, Amir Abdollahi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
human intestinal organoids (hio)
radiotherapy
gastrointestinal (gi) toxicity
particle therapy
carbon ions
personalized medicine
Online Access:https://www.mdpi.com/2072-6694/12/2/469

Internet

https://www.mdpi.com/2072-6694/12/2/469

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