A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

More than 80 years after iron accumulation was initially described in the substantia nigra (SN) of Parkinson's disease (PD) patients, the mechanisms responsible for this phenomenon are still unknown. Similarly, how iron is delivered to its major recipients in the cell – mitochondria and the res...

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Bibliographic Details
Main Authors: Pier Giorgio Mastroberardino, Eric K. Hoffman, Maxx P. Horowitz, Ranjita Betarbet, Georgia Taylor, Dongmei Cheng, Hye Mee Na, Claire-Anne Gutekunst, Marla Gearing, John Q. Trojanowski, Marjorie Anderson, Charleen T. Chu, Junmin Peng, J. Timothy Greenamyre
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Rotenone
Oxidative stress
Mitochondria
Iron
Transferrin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000357

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http://www.sciencedirect.com/science/article/pii/S0969996109000357

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