A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease
More than 80 years after iron accumulation was initially described in the substantia nigra (SN) of Parkinson's disease (PD) patients, the mechanisms responsible for this phenomenon are still unknown. Similarly, how iron is delivered to its major recipients in the cell – mitochondria and the res...
Main Authors: | Pier Giorgio Mastroberardino, Eric K. Hoffman, Maxx P. Horowitz, Ranjita Betarbet, Georgia Taylor, Dongmei Cheng, Hye Mee Na, Claire-Anne Gutekunst, Marla Gearing, John Q. Trojanowski, Marjorie Anderson, Charleen T. Chu, Junmin Peng, J. Timothy Greenamyre |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2009-06-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109000357 |
Similar Items
-
Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents
by: Pierre V. Candelaria, et al.
Published: (2021-03-01) -
Expression of transferrin receptor‐1 (TFR‐1) in canine osteosarcomas
by: Gionata De Vico, et al.
Published: (2020-08-01) -
Ciblage du récepteur de la transferrine de type 1 (TfR1) et du métabolisme du Fer dans le cancer du pancréas
by: Melhem, Rana
Published: (2017) -
Characterization of the Role of Transferrin receptor 1 (Tfr1) in the Intestinal Epithelium, Pancreas and Skin
by: Chen, Alan
Published: (2015) -
Downregulation of TfR1 promotes progression of colorectal cancer via the JAK/STAT pathway
by: Cui C, et al.
Published: (2019-07-01)