Design, Synthesis, Antinociceptive and Anti-Inflammatory Activities of Novel Piroxicam Analogues

Design, Synthesis, Antinociceptive and Anti-Inflammatory Activities of Novel Piroxicam Analogues

In this paper we report the design, synthesis, antinociceptive and anti-inflammatory activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural modification of piroxicam (1), a non steroidal anti-inflammatory drug. Among the synthesized analogues, compounds 1...

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Bibliographic Details
Main Authors: Eliezer J. Barreiro, Lídia Moreira Lima, Rosane de Paula Castro, José Ricardo Sabino, Luciano Morais Lião, Magna Suzana Alexandre-Moreira, Walfrido Bispo Júnior, Yolanda Karla Cupertino da Silva, Amanda Silva de Miranda
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Molecules
Subjects:
piroxicam
inflammation
pain
acylhydrazone
NSAID
COX
Online Access:http://www.mdpi.com/1420-3049/17/12/14126

Internet

http://www.mdpi.com/1420-3049/17/12/14126

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