The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice

The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice

Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A...

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Bibliographic Details
Main Authors: Kelly L. Warfield, Dale L. Barnard, Sven G. Enterlein, Donald F. Smee, Mansoora Khaliq, Aruna Sampath, Michael V. Callahan, Urban Ramstedt, Craig W. Day
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Viruses
Subjects:
Iminosugar
UV-4B
influenza
human bronchial epithelial cells
antiviral
mice
Online Access:http://www.mdpi.com/1999-4915/8/3/71

Internet

http://www.mdpi.com/1999-4915/8/3/71

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