Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if 3-HIB is a marker of human IR and future risk of developing Type 2 diabe...

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Bibliographic Details
Main Authors: Adil Mardinoglu, Silvia Gogg, Luca A. Lotta, Alena Stančáková, Annika Nerstedt, Jan Boren, Matthias Blüher, Ele Ferrannini, Claudia Langenberg, Nicholas J. Wareham, Markku Laakso, Ulf Smith
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:EBioMedicine
Subjects:
3-Hydroxyisobutyric acid (3-HIB)
Branched-chain amino acids (BCAAs)
T2D
Insulin resistance
Insulin secretion
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304899

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http://www.sciencedirect.com/science/article/pii/S2352396417304899

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