Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), and the mechanistic basis for how these ligands inf...

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Bibliographic Details
Main Authors: Amanda J Price, David A Jacques, William A McEwan, Adam J Fletcher, Sebastian Essig, Jason W Chin, Upul D Halambage, Christopher Aiken, Leo C James
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4214760?pdf=render

Internet

http://europepmc.org/articles/PMC4214760?pdf=render

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