Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer

Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer

Background Conventional methods used to identify BRCA1 and BRCA2 germline mutations in hereditary cancers, such as Sanger sequencing/multiplex ligation-dependent probe amplification (MLPA), are time-consuming and expensive, due to the large size of the genes. The recent introduction of next-generati...

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Bibliographic Details
Main Authors: Arianna Nicolussi, Francesca Belardinilli, Yasaman Mahdavian, Valeria Colicchia, Sonia D’Inzeo, Marialaura Petroni, Massimo Zani, Sergio Ferraro, Virginia Valentini, Laura Ottini, Giuseppe Giannini, Carlo Capalbo, Anna Coppa
Format: Article
Language:English
Published: PeerJ Inc. 2019-04-01
Series:PeerJ
Subjects:
Next-generation sequencing
Hereditary breast/ovarian cancer
DNA testing
BRCA1
BRCA2
Online Access:https://peerj.com/articles/6661.pdf

Internet

https://peerj.com/articles/6661.pdf

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