Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice

Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations cause neuronal ceroid lipofuscinosis (NCL). Aged progranulin-knockout mice display highly exaggerated lipo...

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Bibliographic Details
Main Authors: Terri L. Petkau, Jake Blanco, Blair R. Leavitt
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Neurobiology of Disease
Subjects:
Frontotemporal lobar degeneration
Neuronal ceroid lipofuscinosis
Progranulin
Conditional knockout mice
Neuropathology
Nestin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301390

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http://www.sciencedirect.com/science/article/pii/S0969996117301390

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