Aging is not associated with proteasome impairment in UPS reporter mice.

Aging is not associated with proteasome impairment in UPS reporter mice.

Covalent linkage of ubiquitin regulates the function and, ultimately, the degradation of many proteins by the ubiquitin-proteasome system (UPS). Given its essential role in protein regulation, even slight perturbations in UPS activity can substantially impair cellular function.We have generated and...

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Bibliographic Details
Main Authors: Casey Cook, Jennifer Gass, Judith Dunmore, Jimei Tong, Julie Taylor, Jason Eriksen, Eileen McGowan, Jada Lewis, Jennifer Johnston, Leonard Petrucelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2690827?pdf=render

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http://europepmc.org/articles/PMC2690827?pdf=render

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