Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies

Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies

A new series of 5,5-diphenylhydantoin derivatives containing benzylidene or isatin (4–19) was synthesized. Their anticancer activity against HeLa, a cervical cancer cell line, A549, a lung cancer cell line, and MDA-MB-231, a breast cancer cell line, was evaluated. Compounds 13, 16, 17 and 18 exhibit...

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Bibliographic Details
Main Authors: Hamad M. Alkahtani, Mohammed M. Alanazi, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Ali Alhoshani, Fawaz E. Alanazi, Abdulrahman A. Almehizia, Ashraf N. Abdalla, Mashael G. Alanazi, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Saudi Pharmaceutical Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016419300532

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http://www.sciencedirect.com/science/article/pii/S1319016419300532

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