Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice

Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice

Abstract The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated cirrhosis. Cell therapies, such as mesenchymal stem cell (MSC) and macrophage ther...

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Bibliographic Details
Main Authors: Shunsuke Nojiri, Atsunori Tsuchiya, Kazuki Natsui, Suguru Takeuchi, Takayuki Watanabe, Yuichi Kojima, Yusuke Watanabe, Hiroteru Kamimura, Masahiro Ogawa, Satoko Motegi, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Yui Ishii, Tomomi Kitayama, Yu-Tung Li, Yuya Ouchi, Takashi Shimbo, Masaaki Takamura, Katsuto Tamai, Shuji Terai
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Inflammation and Regeneration
Subjects:
HMGB1
Peptide
Liver
Cirrhosis
Fibrosis
Mesenchymal stem cell
Online Access:https://doi.org/10.1186/s41232-021-00177-4

Internet

https://doi.org/10.1186/s41232-021-00177-4

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