Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas

Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas

Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in several different subtypes of cutaneous T-cell lymphoma (C...

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Bibliographic Details
Main Authors: Pilvi Maliniemi, Kirsi Laukkanen, Liisa Väkevä, Katja Dettmer, Tuomas Lipsanen, Leila Jeskanen, Alban Bessede, Peter J. Oefner, Marshall E. Kadin, Annamari Ranki
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:OncoImmunology
Subjects:
cutaneous t-cell lymphoma
immunosuppressive microenvironment
indoleamine 2,3-dioxygenase 1
kynurenine
tryptophan 2,3-dioxygenase
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1273310

Internet

http://dx.doi.org/10.1080/2162402X.2016.1273310

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