Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes

Background: Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS is determined by gene-environment interactions and improved understanding of these interactions may lead to effective personalised medicine. The role of physical exercise in the development of ALS i...

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Bibliographic Details
Main Authors: Thomas H Julian, Nicholas Glascow, A Dylan Fisher Barry, Tobias Moll, Calum Harvey, Yann C Klimentidis, Michelle Newell, Sai Zhang, Michael P Snyder, Johnathan Cooper-Knock, Pamela J Shaw
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:EBioMedicine
Subjects:
Amyotrophic lateral sclerosis
Mendelian randomisation
Physical exercise
C9ORF72
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001900

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421001900

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