The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds

The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds

An mRNA gene therapy represents a potentially promising therapeutic for curing inflammatory diseases. The transient nature of the gene expression of mRNA would be expected to be beneficial for avoiding undesired side effects. Since the mRNA is a vulnerable molecule, a development of a carrier that c...

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Bibliographic Details
Main Authors: Hiroki Tanaka, Ayaka Watanabe, Manami Konishi, Yuta Nakai, Hiroki Yoshioka, Tatsuya Ohkawara, Hiroshi Takeda, Hideyoshi Harashima, Hidetaka Akita
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Heliyon
Subjects:
Materials chemistry
Pharmaceutical science
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018332481

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http://www.sciencedirect.com/science/article/pii/S2405844018332481

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