Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model

Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model

ABSTRACT Calcilytics are calcium‐sensing receptor (CaSR) antagonists that reduce the sensitivity of the CaSR to extracellular calcium. Calcilytics have the potential to treat autosomal dominant hypocalcemia type 1 (ADH1), which is caused by germline gain‐of‐function CaSR mutations and leads to sympt...

Full description

Bibliographic Details
Main Authors: Fadil M Hannan, Caroline M Gorvin, Valerie N Babinsky, Mie K Olesen, Michelle Stewart, Sara Wells, Roger D Cox, Edward F Nemeth, Rajesh V Thakker
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:JBMR Plus
Subjects:
ENDOCRINE PATHWAYS
GENETIC ANIMAL MODELS
HORMONE REPLACEMENT/RECEPTOR MODULATORS
PARATHYROID‐RELATED DISORDERS
Online Access:https://doi.org/10.1002/jbm4.10402

Internet

https://doi.org/10.1002/jbm4.10402

Similar Items