The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation

The class I phosphoinoside-3-kinases (PI3Ks) are important enzymes that relay signals from cell surface receptors to downstream mediators driving cellular functions. Elevated PI3K signaling is found in B cell malignancies and lymphocytes of patients with autoimmune disease. The p110δ catalytic isofo...

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Bibliographic Details
Main Authors: Honyin Chiu, Sharmila Mallya, Phuongthao Nguyen, Annie Mai, Leandra V. Jackson, David G. Winkler, Jonathan P. DiNitto, Erin E. Brophy, Karen McGovern, Jeffery L. Kutok, David A. Fruman
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
phosphoinoside-3-kinase
lipid kinase
B cell survival
B cell proliferation
B cell differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00747/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00747/full

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