The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays

The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays

Abstract Background Schistosomiasis chemotherapy is largely based on praziquantel (PZQ). Although PZQ is very safe and tolerable, it does not prevent reinfection and emerging resistance is a primary concern. Recent studies have shown that the targeting of epigenetic machinery in Schistosoma mansoni...

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Bibliographic Details
Main Authors: Jessica Lobo-Silva, Fernanda J. Cabral, Murilo S. Amaral, Patrícia A. Miyasato, Rafaela Paula de Freitas, Adriana S. A. Pereira, Mariana I. Khouri, Mayra M. F. Barbosa, Pablo I. P. Ramos, Luciana C. C. Leite, Oluwatoyin A. Asojo, Eliana Nakano, Sergio Verjovski-Almeida, Leonardo P. Farias
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Parasites & Vectors
Subjects:
Anthelmintic drug discovery
Epigenetics
Jumonji histone demethylase
Online Access:http://link.springer.com/article/10.1186/s13071-020-4000-z

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http://link.springer.com/article/10.1186/s13071-020-4000-z

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