Effective preparation of Plasmodium vivax field isolates for high-throughput whole genome sequencing.

Effective preparation of Plasmodium vivax field isolates for high-throughput whole genome sequencing.

Whole genome sequencing (WGS) of Plasmodium vivax is problematic due to the reliance on clinical isolates which are generally low in parasitaemia and sample volume. Furthermore, clinical isolates contain a significant contaminating background of host DNA which confounds efforts to map short read seq...

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Bibliographic Details
Main Authors: Sarah Auburn, Jutta Marfurt, Gareth Maslen, Susana Campino, Valentin Ruano Rubio, Magnus Manske, Barbara Machunter, Enny Kenangalem, Rintis Noviyanti, Leily Trianty, Boni Sebayang, Grennady Wirjanata, Kanlaya Sriprawat, Daniel Alcock, Bronwyn Macinnis, Olivo Miotto, Taane G Clark, Bruce Russell, Nicholas M Anstey, François Nosten, Dominic P Kwiatkowski, Ric N Price
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3537768?pdf=render

Internet

http://europepmc.org/articles/PMC3537768?pdf=render

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