An Integrated Analysis of Radial Spoke Head and Outer Dynein Arm Protein Defects and Ciliogenesis Abnormality in Nasal Polyps

An Integrated Analysis of Radial Spoke Head and Outer Dynein Arm Protein Defects and Ciliogenesis Abnormality in Nasal Polyps

Background: Nasal polyp (NP) is a chronic upper airway inflammatory disease that is frequently triggered by defective host-defense. However, the mechanisms underlying the impaired barrier function such as cilia-mediated mucociliary clearance remain poorly understood.Objective: To assess ciliary ultr...

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Bibliographic Details
Main Authors: Xiao-xue Zi, Wei-jie Guan, Yang Peng, Kai Sen Tan, Jing Liu, Ting-ting He, Yew-kwang Ong, Mark Thong, Li Shi, De-yun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
abnormal ciliary ultrastructure
inflammation
inferior turbinate
nasal polyps
mucociliary clearance
up-regulated ciliogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01083/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.01083/full

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