Ankylosing Spondylitis: A Trade Off of HLA-B27, ERAP, and Pathogen Interconnections? Focus on Sardinia

Ankylosing Spondylitis: A Trade Off of HLA-B27, ERAP, and Pathogen Interconnections? Focus on Sardinia

The frequency of HLA-B27 in patients with Ankylosing Spondylitis (AS) is over 85%. There are more than 170 recognized HLA-B27 alleles but the majority of them is not sufficiently represented for genetic association studies. So far only two alleles, the HLA-B*2706 in Asia and the HLA-B*2709 in Sardin...

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Bibliographic Details
Main Authors: Fabiana Paladini, Maria Teresa Fiorillo, Valentina Tedeschi, Alberto Cauli, Alessandro Mathieu, Rosa Sorrentino
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
HLA-B27 alleles
ankylosing spondylitis
ERAP1 and 2
autoimmunity
malaria
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00035/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00035/full

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